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目的 比较两种介入治疗方法的 5 -氟尿嘧啶明胶微球在体内的药物释放特点。方法 在不同时间点取血样并用紫外分光光度法测定局部组织及外周静脉血的血药浓度 ,并进行药代动力学分析。结果 动脉灌注法可以产生局部较高的血药浓度 ,但维持时间较短 ;使用氟尿嘧啶明胶微球进行栓塞可以在较小的用药剂量上在局部维持相对较长时间的较高的血药浓度。结论 氟尿嘧啶明胶微球进行动脉栓塞可以显著降低全身血药浓度及用药剂量 ,达到肿瘤靶向治疗的目的。
Objective To compare the drug release characteristics of 5 - fluorouracil gelatin microspheres in vivo by two interventional methods. Methods Blood samples were collected at different time points and the plasma concentrations of the local tissues and peripheral venous blood were measured by UV spectrophotometry and the pharmacokinetics were analyzed. Results Arterial perfusion method could produce locally higher plasma concentration, but the maintenance time was shorter. The embolization with fluorouracil gelatin microspheres could maintain a relatively high blood concentration locally for a relatively long time at a small dosage. Conclusion Fluorouracil gelatin microspheres for arterial embolization can significantly reduce the systemic blood drug concentration and dose, to achieve the purpose of tumor targeting therapy.