论文部分内容阅读
目的 :比较肌注与口服咪唑安定 (MIZ)、氯胺酮 (KET)混合液的临床效应。方法 :ASAⅠ级 ,年龄 2～ 6岁择期手术患儿40例 ,随机分为两组 ,每组 2 0例。A组术前 3 0min肌注MIZ 0 1mg/kg +KET 1mg/kg混合液 ;B组术前 3 0min口服MIZ 0 5mg/kg+KET 5mg/kg混合液 ,容量为 0 2 5ml/kg ,用果汁配制。待小儿镇静后行骶管阻滞。观察并记录小儿对两种给药途径的接受程度 ;用药后的HR、RR、SpO2 变化 ;记录用药后的显效时间 ,首次睁眼时间 ;评估用药后小儿的镇静、情绪状态、与家长分离和静脉穿刺时的行为变化以及用药后出现的不良反应。结果 :A组小儿 10 0 %反对肌注 ,B组 90 %容易接受口服液 ;A组小儿用药后HR、RR均加快 ,与用药前比较差异显著 (P <0 0 5 ) ;两组用药后行为变化无明显差异 (P >0 0 5 ) ,A组显效时间比B组快 (P <0 0 5 ) ;两组均无明显不良反应。结论 :两组术前给药方案用于小儿 ,镇静效果良好 ,与肌注途径比较 ,口服给药具有无痛苦、小儿易接受、安全等优点 ,因此更适合于小儿
Objective: To compare the clinical effects of intramuscular and oral administration of midazolam (MIZ) and ketamine (KET). Methods: Forty ASA Ⅰ-age children aged 2 to 6 years undergoing elective surgery were randomly divided into two groups (20 in each group). Group A received intramuscular injection of MIZ 0 1mg / kg + KET 1mg / kg at 30 minutes before operation; Group B received oral MIZ 0 5mg / kg + KET 5mg / kg at 30 minutes before operation with a volume of 0 25ml / Fruit juice preparation. Pediatric sacral block until calm. Observe and record the children’s acceptance of the two routes of administration; HR, RR, SpO2 changes after treatment; record the effective time after the medication, the first time to open eyes; assessment of sedation, emotional state, separation of parents and parents after treatment Venous puncture behavior changes and adverse reactions after treatment. Results: 10% of children in group A opposed intramuscular injection, and 90% of group B was easy to take oral solution. After treatment, the HR and RR of children in group A accelerated, which was significantly different from that before treatment (P <0.05) There was no significant difference in behavior between the two groups (P> 0.05). The effective time of group A was faster than that of group B (P <0.05). There was no obvious adverse reaction in both groups. Conclusion: The two groups of preoperative dosing regimen for children, good effect of sedation, compared with the intramuscular route, oral administration with no pain, pediatric easy to accept, safety, etc., and therefore more suitable for children