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给清醒大鼠脑室内注射去甲肾上腺素或氯压定(Clonidine),前者表现、而后者无抗利尿效应;但脑室内分别注射以上两药,均能使同时皮下注射盐酸吗啡的抗利尿效应减弱;脑室内注射酚妥拉明(Phentolmine)或酚苄明(Phenoxybenzamine)均有抗利尿效应,并加强同时皮下注射盐酸吗啡的抗利尿效应。给小鼠脑室内注射酚苄明或酚妥拉明或育亨宾(Yohimbine),均有镇痛效应;以上三药镇痛ED_(20)注射于小鼠脑室内,均能分别加强同时皮下注射盐酸吗啡的抗痛效应,但以酚苄明加强作用最显著。以上结果提示脑内α-受体的功能增强可拮抗吗啡抗利尿效应,反之亦然;吗啡抗痛与脑内突触后膜α-受体部位去甲肾上腺素功能减弱有密切关系。
To the awake rat intraventricular injection of norepinephrine or clonidine (Clonidine), the former performance, while the latter without anti-diuretic effect; but intracerebroventricular injection of these two drugs were able to subcutaneous injection of morphine hydrochloride, the antidiuretic effect (Phentolmine or Phenoxybenzamine) had an anti-diuretic effect and enhanced the anti-diuretic effect of simultaneous subcutaneous injection of morphine hydrochloride. Intravenous injection of phenoxybenzamine or phentolamine or yohimbine in mice resulted in analgesic effects. All of the above three analgesic drugs, ED 20 injected into the ventricles of mice, could enhance the simultaneous subcutaneous Injection of morphine hydrochloride analgesic effect, but the phenoxybenzamine strengthen the role of the most significant. The above results suggest that the functional enhancement of α -receptor in the brain may antagonize the anti-diuretic effect of morphine, and vice versa. Morphine may be associated with weakened norepinephrine function in the α-receptor site of the postsynaptic membrane.