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胃泌素瘤系Zollinger和Ellison于1955首先描述的一种综合征(Z-E综合征),其特征是伴有显著高胃酸分泌的致命性消化性溃疡和胰腺非β细胞瘤(胃泌素瘤)。以往,对其严重消化性溃疡常在紧急情况下作全胃切除术予以治疗。自经H_2受体阻滞剂以及新近的质子泵抑制剂(奥美拉唑)问世后几乎每一个患者的高胃酸分泌均能用药物长期控制,并能作出早期诊断,很少死于消化性溃疡的并发症。目前认为,决定病人长期成活的主要因素是胃泌素瘤的生长和其转移的潜在能力,而对胃泌素瘤越来越强调直接处理可以增加长期存活。其根据是:1.最初认为胃泌素瘤生长缓慢,然而,最近对全胃切除存活者的胃泌素瘤长期随访表明,至少50%死亡者是由于肿瘤的发展,2.全胃切除与药物治疗均不能阻止肿瘤的
Gastrinoma is a syndrome (ZE syndrome) first described by Zollinger and Ellison in 1955 and is characterized by fatal peptic ulcers and pancreatic non-beta-cell neoplasia (gastrinoma) accompanied by markedly elevated gastric acid secretion. . In the past, severe peptic ulcers were often treated for total gastrectomy in emergency situations. Since the introduction of H_2 receptor blockers and the recent introduction of proton pump inhibitors (omeprazole), high gastric acid secretion in almost every patient can be controlled by drugs for a long period of time, and early diagnosis can be made, seldom due to peptic Ulcer complications. It is currently believed that the main factor that determines the long-term survival of patients is the potential for gastrinoma growth and its potential for metastasis, and the increasing emphasis on gastrinoma direct treatment can increase long-term survival. Its basis is as follows: 1. Gastrin tumors were initially thought to be slow to grow, however, the recent long-term follow-up of gastrinomas in survivors of total gastrectomy showed that at least 50% of those who died were due to the development of tumors. 2. Total gastrectomy and Drug therapy can not stop the tumor