血清唾液酸测定对原发性肝癌的诊断意义

• 作 者: 刘金兰 蔡至道 刘荣亭 张岐山 张玉魁 车龙浩 冯领弟
• 机 构: 中国医科大学附属第一医院内科,中国医科大学附属第一医院内科,中国医科大学附属第一医院内科,中国医科大学生物化学教研室,中国医科大学生物化学教研室,中国医科大学生物化学教研室,中国医科大学生物化学教研室
• 出 处: 实用内科杂志
• 发表日期: 1991年11期
• 关键词: 原发性肝癌 血清唾液酸 良性肝病 肝转移癌 硬化肝 健康人血清 腹静脉 肝血 鉴别诊断 人肝

本文通过对原发性肝癌、良性肝病和健康人血清唾液酸的研究表明,原发性肝癌患者血清唾液酸水平明显增高(2.960±0.707mmol/L),与良性肝病及健康人相比有显著差异(P<0.01)。血清唾液酸对原发性肝癌的诊断特异度为84.4%,敏感度为78.72%(P<0.01),尤其是时AFP阴性的原发性肝癌阳性率为71.43%。据此认为,血清唾液酸是原发性肝癌诊断和鉴别诊断的较好标记物之一。

In this paper, studies on serum sialic acid in primary liver cancer, benign liver disease, and healthy people showed that serum sialic acid levels in patients with primary liver cancer were significantly higher (2.960±0.707 mmol/L), which was significantly higher than that in benign liver disease and healthy people. Difference (P<0.01). The diagnostic specificity of serum sialic acid for primary hepatocellular carcinoma was 84.4%, and the sensitivity was 78.72% (P<0.01). In particular, the positive rate of AFP negative primary hepatocellular carcinoma was 71.43%. According to this, serum sialic acid is one of the better markers for the diagnosis and differential diagnosis of primary liver cancer.