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目的探讨孕妇弓形虫(TOX)感染的状况及不同感染状况对妊娠结局的影响。方法用酶联免疫吸附法检测孕妇血中弓形虫IgG及IgM抗体,根据检验结果组成急性感染组、活动性感染组、既往感染组,随机抽取无感染者作对照组,比较4组妊娠结局。结果比较妊娠结局急性感染组流产、胎停、早产、出生缺陷的发生明显高于活动性感染组、既往感染组和无感染组,P<0.05;活动性感染组明显高于既往感染和无感染组,P<0.05;既往感染和无感染组无差异,P>0.05。结论①孕妇Tox急性感染者不良妊娠结局的发生高于活动性感染者。②Tox既往感染者孕期风险取决于是否发生Tox再次感染或激发感染复发。
Objective To investigate the status of TOX infection in pregnant women and the influence of different infection status on pregnancy outcome. Methods Toxoplasma gondii IgG and IgM antibodies in pregnant women were detected by enzyme-linked immunosorbent assay (ELISA). According to the test results, acute infection group, active infection group and previous infection group were randomly divided into control group and non-infected group. The pregnancy outcomes were compared between the four groups. Results The incidence of miscarriage, fetal stop, premature birth and birth defects in acute infection group was significantly higher than that in active infection group, previous infection group and non-infection group, P <0.05; active infection group was significantly higher than those of previous infection and no infection Group, P <0.05; no difference between the former infection and the non-infection group, P> 0.05. Conclusion ① The incidence of adverse pregnancy outcomes in pregnant women with acute Tox infection is higher than those with active infection. (2) Pregnancy risk in patients with previous HIV infection depends on whether Tox re-infection occurs or the relapse of infection is triggered.