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采用放射免疫分析法对38例胃癌患者进行了手术前后的血清β_2—微球蛋白(β_2-M),癌胚抗原(CEA)水平的测定,结果表明:胃癌病人手术前CEA、β_2-M明显高于正常人,而根治术后则明显下降。因广泛转移而不能行根治术者或仅行姑息性切除的病人,术前术后CEA及β_2-M改变不明显。又对13例胃癌根治术后1～2年患者进行测定表明:若有复发或广泛转移β_2-M及CEA均明显升高,伴肝转移时,二者升高更为显著。
Radioimmunoassay was used to detect serum β2-microglobulin (β2-M) and carcinoembryonic antigen (CEA) levels in 38 patients with gastric cancer before and after surgery. The results showed that preoperative CEA and β_2-M were significantly different in gastric cancer patients. Higher than normal, but significantly decreased after radical surgery. Patients who could not undergo radical resection because of extensive metastasis or who had palliative resection only had no significant change in preoperative and postoperative CEA and β_2-M. In addition, 13 patients who underwent radical gastrectomy for 1 to 2 years showed that if there is recurrence or extensive metastasis, both β_2-M and CEA are significantly elevated, and when they have liver metastases, the two are more significantly elevated.