Changing the paradigm：the potential for targeted therapy in laryngeal squamous cell carcinoma

• 作 者: Megan L.Ludwig Andrew C.Birkel
• 机 构: DepartmentofOtolaryngologyHeadandNeckSurgery,CellularandMolecularBiologyProgram,DepartmentofHematolo
• 出 处: 癌症生物学与医学：英文版
• 发表日期: 2016年1期
• 关键词: 鳞状细胞癌 靶向治疗 个性化 癌症治疗 模型系统 疾病 历史 保存 Head and neck cancer laryngeal squamous cell c
• 基金项目: J. Chad Brenner received funding from NIH （Grants No. U01DE025184 and P30： CA046592 S1）, Andrew C. Birkeland and Rebecca Hoesli received support from University of Michigan Otolaryngology Resident Res

Laryngeal squamous cell carcinoma(LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few de