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生长抑素(SST)是一种广泛分布于胃肠道、神经系统的脑肠肽,对其在应激中的变化及其机制的报道很少。本文旨在探讨强迫游泳所致的应激状态下大鼠胃肠组织和神经系统内免疫反应性生长抑素(IRS)的变化及纳洛酮的影响。 实验用30只雄性Wistar大鼠,随机分为三组,每组10只。正常组:不经任何处理;应激组:大鼠在22±2℃的水中游泳15min,游泳前20min肌注生理盐水(1ml/kg)作为对照;纳洛酮组:在游泳前20min肌注纳洛酮(1mg/kg)。
Somatostatin (SST) is a widely distributed in the gastrointestinal tract, nervous system, brain gut peptide, its changes in stress and its mechanism is rarely reported. The purpose of this article is to investigate the changes of immunoreactive somatostatin (IRS) and naloxone in rat gastrointestinal tissues and nervous system under forced swimming. Thirty male Wistar rats were randomly divided into three groups of 10 rats each. Normal group: without any treatment; stress group: rats swimming in water at 22 ± 2 ℃ for 15 minutes, 20 minutes before swimming intramuscular injection of normal saline (1ml / kg) as a control; naloxone group: 20min before swimming intramuscularly Naloxone (1 mg / kg).