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目的:探讨伴高血压的冠心病患者心率减速力(DC)、血清同型半胱氨酸(Hcy)水平与冠状动脉病变范围及程度的相关性。方法:选取2019年1－10月在滨州市中心医院心血管内科确诊并住院治疗的伴高血压的冠心病患者103例为冠心病组，52例单纯高血压患者为对照组。测定并分析两组患者的血清Hcy水平。行24 h动态心电图检查，分析两组患者的DC值及差异。冠心病组患者冠状动脉病变程度通过冠状动脉病变支数和Gensini评分评价。分析两组患者DC值、血清Hcy水平及与冠状动脉病变程度的相关性。结果:冠心病组DC值明显低于对照组[(4.97±1.59)ms比(6.02±1.97)ms，n t＝－3.989，n P<0.05]，血清Hcy水平高于对照组[(16.79±6.31)μmol/L比(11.46±4.38)μmol/L，n t＝4.260，n P<0.05]。冠心病组冠状动脉单支病变、双支病变和三支病变患者的DC值和Gensini评分分别为(5.52±1.34)ms、(5.06±1.29)ms、(4.39±1.19)ms，(21.35±17.10)分、(26.93±18.18)分、(49.39±30.14)分，三支病变患者DC值较单支病变患者减小(n F＝7.349，n P<0.05)，Gensini评分升高(n F＝13.487，n P0.05)。冠状动脉单支病变、双支病变、三支病变患者血清Hcy水平分别为(14.67±5.97)μmol/L、(15.85±6.29)μmol/L、(16.97±7.13)μmol/L，三者差异有统计学意义(n F＝12.427，n P<0.05)。冠心病组DC值与Gensini评分呈负相关(n r＝－0.310，n P<0.05)，血清Hcy水平与Gensini评分呈正相关(n r＝0.369，n P<0.05)。n 结论:伴高血压的冠心病患者DC值显著减小，血清Hcy水平明显升高，两者与冠状动脉病变程度密切相关。“,”Objective:To explore the correlation between the level of heart rate deceleration (DC), serum homocysteine(Hcy), the scope and extent of coronary artery lesion in coronary heart disease patients with hypertension.Methods:From January 2019 to October 2019, 103 coronary heart disease patients with hypertension who were diagnosed and hospitalized in cardiovascular department of Binzhou Central Hospital were selected as coronary heart disease(CHD) group, and 52 patients with simple hypertension were selected as control group.The serum Hcy levels of the two groups were measured and analyzed.The DC value and the difference of the two groups were analyzed.The degree of coronary artery lesion was evaluated by the number of coronary artery lesion and Gensini score.The relationship between DC, Hcy and the degree of coronary artery lesion was analyzed.Results:Compared with the control group, the DC value of CHD group was significantly lower [(6.02±1.97)ms vs.(4.97±1.59)ms, n t=-3.989, n P<0.05], and the serum Hcy level was increased [(11.46±4.38)μmol/L vs.(16.79±6.31)μmol/L,n t=4.260, n P<0.05]. In the CHD group, the DC values and Gensini scores of the patients with single vessel lesion, double vessel lesions and three vessel lesions were (5.52±1.34)ms, (5.06±1.29)ms, (4.39±1.19)ms, (21.35±17.10)points, (26.93±18.18)points, (49.39±30.14)points, respectively.The DC value of patients with three vessel lesions was lower than that of patients with single vessel lesion(n F=7.349, n P<0.05), and the Gensini score was higher(n F=13.487, n P0.05). The serum Hcy levels of patients with single, double and three vessel lesions were (14.67±5.97)μmol/L, (15.85±6.29)μmol/L and (16.97±7.13)μmol/L, respectively.The difference among the three groups was statistically significant (n F=12.427, n P<0.05). There was a negative correlation between DC and Gensini score(n r=-0.310, n P<0.05), and a positive correlation between serum Hcy and Gensini score(n r=0.369, n P<0.05).n Conclusion:The DC value and Hcy level in coronary heart disease patients with hypertension are significantly decreased, which are closely related to the degree of coronary artery lesion.