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对硝酸稀土的急性毒性进行了研究。(1)经口半数致死剂量测定,用寇氏法对雌雄各半的大鼠及雌性小鼠随机分组,隔夜停食,灌胃染毒,以氧化物计LD_(50)为997毫克/公斤和990毫克/公斤,用粗略法给雌性豚鼠染毒,LD_(50)为737毫克/公斤,结果属低毒物质。(2)选无皮肤疾患家兔6只于背部进行四种浓度的斑贴试验,观察皮肤反应。选无眼部疾患的家兔6只,右眼用硝酸溶液作对照,左眼结膜囊染毒观察变化,按标准评定结果,硝酸稀土对皮肤原发刺激指数为2～5,具有中等度刺激作用,对眼粘膜具有轻度刺激作用。
Acute toxicity of rare earth nitrate was studied. (1) The oral half lethal dose was measured. The male and female rats and female mice were randomly divided into two groups according to the Kou’s method. The rats were fasted for overnight and gavage. The LD50 of the LD50 was 997 mg / kg and 990 mg / kg. The female guinea pigs were exposed to the crude method with a LD 50 value of 737 mg / kg. The result was a low toxic material. (2) choose no skin disease rabbits in the back of the four concentrations of the patch test to observe the skin reaction. Six rabbits without ocular disorders were selected. The right eye was treated with nitric acid solution and the conjunctival sac of the left eye was observed for changes. According to the standard evaluation results, the primary irritation index of rare earth nitrate to skin was 2 to 5, with moderate stimulation Role of the eye mucosa with mild stimulation.