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目的探讨应用二甲双胍促进多囊卵巢综合征排卵的应用效果。方法选取2011年1月至2012月12月收治的90例多囊卵巢综合征患者,将其按照随机数字法分为三组,A组给予二甲双胍进行治疗,B组给予达因-35治疗,C组给予克罗米芬治疗,观察三组的应用效果。结果治疗后三组的黄体生成激素、空腹胰岛素、促卵泡激素、睾酮、瘦素较治疗前均有不同程度的改善,A组改善效果优于B组和C组(P<0.05);B组和C组治疗后改善情况无明显的差异(P>0.05)。A组的排卵率、妊娠率明显高于B组和C组(P<0.05);A组的早期流产率明显低于B、C两组(P<0.05)。不良反应发生率A组6.7%;B组10.0%;C组10.0%;三组比较无明显的差异(P>0.05)。结论二甲双胍能够较好的促进多囊卵巢综合征患者的排卵,提高妊娠率,并能较好维持体内性激素平衡,治疗安全性高。
Objective To explore the application of metformin to promote ovulation in patients with polycystic ovary syndrome. Methods Ninety patients with PCOS who were admitted from January 2011 to December 2012 were divided into three groups according to random number method: group A was treated with metformin; group B was given darin -35; group C was treated with C Group treated with clomiphene, observed the effect of three groups. Results After treatment, the levels of luteinizing hormone, fasting insulin, follicle stimulating hormone, testosterone and leptin were all improved to some extent in the three groups. The improvement in group A was better than that in group B and C (P <0.05) There was no significant difference between group C and group C after treatment (P> 0.05). The ovulation rate and pregnancy rate in group A were significantly higher than those in group B and C (P <0.05). The rate of early miscarriage in group A was significantly lower than that in group B and C (P <0.05). The incidence of adverse reactions was 6.7% in group A, 10.0% in group B and 10.0% in group C, with no significant difference between the three groups (P> 0.05). Conclusion Metformin can promote the ovulation in patients with PCOS better, increase the pregnancy rate, maintain the balance of sex hormones in the body and have high safety.