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应用流式细胞免疫荧光及双抗体染色检测技术，对３９例口腔颌面部鳞癌细胞ＤＮＡ指数、增殖指数及ｐ２１基因产物的表达进行了定量分析。结果表明：口腔颌面部鳞癌ＤＮＡ异倍体率及增殖指数与肿瘤病理组织学分级有明显的相关性；在口腔颌面部鳞癌组织中，ｐ２１基因产物呈高阳性表达（８２．０５％），异倍体肿瘤中ｐ２１表达阳性率及表达强度均略高于二倍体肿瘤，但ｐ２１基因产物的表达强度与肿瘤的病理组织学分级无显著相关性。因此，ｐ２１基因产物的检测可以作为判断良恶性肿瘤及肿瘤筛查的一个指标，而不能作为判断肿瘤恶性度的指标。
The DNA index, proliferation index and the expression of p21 gene in 39 cases of oral squamous cell carcinoma were quantitatively analyzed by flow cytometry and double antibody staining. The results showed that the DNA aneuploidy rate and proliferation index of oral and maxillofacial squamous cell carcinoma were significantly correlated with tumor histological grade. The expression of p21 gene in oral and maxillofacial squamous cell carcinoma was highly positive (82.05 %). The positive rate and the expression level of p21 in aneuploid tumors were slightly higher than those in diploid tumors. However, there was no significant correlation between the expression of p21 gene and pathological grade of tumor. Therefore, the detection of p21 gene product can be used as an indicator of benign and malignant tumors and tumor screening, but not as an indicator of malignancy.