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血清中巨CK-1型是由CK同工酶与Ig结合而成,通常是CK-BB与单克隆IgG的K轻链以克分子比1:1或2:1结合在Fab或F(ab’)_2片段上。电泳区带位于CK-MM与CK-MB间,也可存在于CK-MB(CK-IgG复合物)或CK-MM(CK-IgA复合物)的位置。巨CK-2型是寡聚线粒体CK的代表,其迁移率,高活性,酶的动力学及耐热均表明其来源于线粒体。通常巨CK-2型是总CK活力的25％,而巨CK-1型为10％。作者等从8322名做过CK同工酶分析的病人中鉴定出136名血清中存有巨CK同工酶,其中36例为1型,100例为2型,大约3/4为非卧床病人。68名中大约90％在发现巨CK后至少存
Serum CK-1 type is a combination of CK isoenzymes and Ig, usually K-chain of CK-BB and monoclonal IgG at a molar ratio of 1: 1 or 2: 1 in Fab or F (ab ’) _2 fragment. The electrophoresis zone is located between CK-MM and CK-MB and may also exist at the site of CK-MB (CK-IgG complex) or CK-MM (CK-IgA complex). The giant CK-2 is representative of oligomeric mitochondria CK, and its mobility, high activity, enzyme kinetics, and heat tolerance all indicate that it is derived from mitochondria. Generally, giant CK-2 type is 25% of the total CK activity, while giant CK-1 type is 10%. Of the 8322 patients who underwent CK isoenzyme analysis, the authors identified 136 CK isozymes in 136 sera, of which 36 were type 1, 100 were type 2 and about 3/4 were in-ambulatory patients . Approximately 90% of 68 out of stocks found at least a giant CK