The crosstalk between autophagy and ferroptosis:what can we learn to target drug resistance in cance

• 作 者: Yulu Zhou Yong Shen Cong Chen
• 机 构: DepartmentofSurgicalOncology,BiomedicalResearchCenterandKeyLaboratoryofBiotherapyofZhejiangProvinee,
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2019年4期
• 关键词: AUTOPHAGY ferroptosis CROSSTALK CANCER DRUG resistance
• 基金项目: supported by the National Natural Science Foundation of China(Grant No.81602471,81672729,81672729,81874380 and 81672932),Zhejiang Provincial Natural Science Foundation of China under Grants(Grant No.L

Autophagy is a conserved intracellular degradation system that plays a dual role in cell death;thus,therapies targeting autophagy in cancer are somewhat controversial.Ferroptosis is a new form of regulated cell death featured with the iron-dependent accum