The challenge of drug resistance in pancreatic ductal adenocarcinoma:a current overview

• 作 者: Francisco Quinonero Cristina M
• 机 构: InstituteofBiopathologyandRegenerativeMedicine（IBIMER）,DepartmentofAnatomyandEmbryology,InstitutoBio
• 出 处: 癌症生物学与医学:英文版
• 发表日期: 2019年4期
• 关键词: PANCREATIC DUCTAL ADENOCARCINOMA chemotherapy drug resistance cancer stem cells
• 基金项目: funded by grants from Instituto de Salud Carlos Ⅲ(Grant No.DTS15/00201 and DTS17/00081),Junta de Andalucía(Grant No.PIN-0474-2016)

Pancreatic ductal adenocarcinoma(PDAC)has one of the highest mortality rates among all cancer types.Its delayed diagnosis precludes curative resection,thus most of the current therapies against PDAC are based on chemo-and radiotherapy.Unfortunately,these