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米非司酮(Ru486)是一种新型甾体类抗早孕激素药,研究证明,它具有终止早孕、抗着床、诱导月经和软化宫颈的作用,继而发现Ru486还能明显增高妊娠子宫对外源性前列腺素的敏感性.因此,联合应用小剂量Ru486与前列腺素类药物已成为当今最成功的抗旱孕药物.自1983年以来已有9万余例法国妇女采用此方法终止早孕,1991年底我国试制Ru486成功,经卫生部新药审批办同意开展临床试验, 近年来开始推广使用,我院自1992年11月～1993年11月对闭经≤49天的500例早孕、健康、自愿药物流产的妇女临床观察效果报告如下.
Mifepristone (Ru486) is a new type of steroid anti-progesterone hormone. Studies have shown that it has the effect of terminating early pregnancy, anti-implantation, inducing menses and softening the cervix. Ru486 has also been found to significantly increase the rate of uterine pregnancy Therefore, the combination of low doses of Ru486 and prostaglandins has become the most successful anti-drought drug today, and more than 90,000 French women have used this method to terminate early pregnancy since 1983. At the end of 1991, China Trial Ru486 success, approved by the Ministry of Health Drug Approval Office agreed to carry out clinical trials, in recent years began to promote the use of our hospital from November 1992 to November 1993 for amenorrhea ≤ 49 days of 500 cases of early pregnancy, healthy, voluntary medical abortion of women Clinical observation results are as follows.