论文部分内容阅读
目的:探讨老年代谢综合征(MS)患者颈动脉内膜中层厚度(IMT)与血管内皮功能及血管粘附因子-1(VCAM-1)的相关性。方法:选取2013年1月~2014年10月我院收治的50例MS患者分为老年组(n=25)和中青年组(n=25),又根据IMT分为正常组和增厚组两个亚组。比较老年组和中青年组患者的临床资料,采用放射免疫分析法检测所有患者内皮素-1(ET-1)水平,采用分光光度计间接比色法检测一氧化氮(NO)水平,采用ELISA法检测VCAM-1水平,采用超声诊断仪检测IMT。结果:老年MS组和中青年MS组临床资料比较,差异均无统计学意义(均P>0.05);MS患者IMT增厚组的NO水平均低于IMT正常组,而ET-1和VCAM-1水平均高于IMT正常组,比较差异有统计学意义(均P<0.05)。IMT增厚组间比较,老年MS组的NO水平低于中青年MS组,VCAM-1水平高于中青年MS组,比较差异均有统计学意义(P<0.05);老年MS组和中青年MS组的IMT与NO水平呈负相关(r=-0.415,-0.411;P=0.043,0.049),与ET-1和VCAM-1水平呈正相关(r=0.585,0.576;P=0.030,0.036;r=0.547,0.552;P=0.033,0.031)。结论:血管内皮功能障碍和动脉粥样硬化等多重因素促进了MS患者IMT增厚中病理过程的发生和发展。
Objective: To investigate the relationship between carotid intima-media thickness (IMT) and vascular endothelial function and vascular adhesion molecule-1 (VCAM-1) in elderly patients with metabolic syndrome (MS). Methods: Fifty patients with MS who were admitted to our hospital from January 2013 to October 2014 were divided into the elderly group (n = 25) and the middle-aged and young group (n = 25), and then divided into normal group and thickening group according to IMT Two subgroups. The clinical data of elderly patients and middle-aged patients were compared. The levels of ET-1 in all patients were measured by radioimmunoassay. Nitric oxide (NO) level was measured by indirect colorimetric assay. Method to detect the level of VCAM-1, using ultrasonic diagnostic apparatus to detect IMT. Results: There was no significant difference in the clinical data between the elderly MS group and the middle-aged and young MS group (all P> 0.05). The NO level in MS patients with IMT thickening group was lower than that in normal IMT group, while ET-1 and VCAM- 1 levels were higher than the IMT normal group, the difference was statistically significant (P <0.05). Compared with young MS group, the level of NO in senile MS group was lower than that in middle-aged MS group, and the level of VCAM-1 was higher than that in middle-aged MS group (P <0.05) There was a negative correlation between IMT and NO levels in MS group (r = -0.415, -0.411; P = 0.043,0.049), and positively correlated with ET-1 and VCAM-1 levels r = 0.547, 0.552; P = 0.033, 0.031). Conclusion: Multiple factors such as vascular endothelial dysfunction and atherosclerosis promote the occurrence and development of pathological processes in IMT thickened MS patients.