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本文通过对醋己氨酸锌(zinc acexamate,ZAC)进行的研究,综述了锌在胃溃疡病方面的治疗作用。有机锌化合物ZAC具有实验性抗溃疡作用和治疗指征广,因而已成为治疗消化性溃疡的有效药物。ZAC对几个溃疡形成的模型如幽门梗阻、利血平诱发溃疡、致坏死剂性溃疡、PAF诱发溃疡和冷冻应激反应,都能起保护作用。其作用机制可能是首先通过膜的稳定作用,抑制肥大细胞脱颗粒,减少胃酸分泌。再就是通过增加胃粘膜保护因子,阻止H~+逆行扩散,改善微循环。ZAC不但对醋酸所致的慢性溃疡有效,而且对胃粘膜损害的继续蔓延也有修复作用。一些临床试验已经证明ZAC在胃和十二指肠溃疡的急性期和维持期治疗的有效性。内窥镜观察表明ZAC可缩短与溃疡愈合有关的炎症过程(胃炎和十二指肠炎)。这一过程的缩短是其它对照治疗(H_2-受体阻滞剂)所不及的,具有统计学的显著意义。且副作用很小,低于2%。鉴于ZAC的临床效果和耐受性强,因而在消化性疾病的治疗中是值得选用的药物。
In this paper, the research on zinc acexamate (ZAC) is reviewed, and the therapeutic effect of zinc on gastric ulcer is reviewed. Zinc has an experimental anti-ulcer effect and a wide range of indications for treatment and has become an effective drug for the treatment of peptic ulcer. ZAC has protective effects on several models of ulcer formation, such as pyloric obstruction, reserpine-induced ulcer, necrotic ulcer, PAF-induced ulcer and cryogenic stress response. The mechanism may be the first through the membrane stabilizing effect, inhibit mast cell degranulation, reduce gastric acid secretion. And then by increasing the gastric mucosal protective factor to prevent retrograde H ~ + diffusion, improve microcirculation. ZAC is not only effective for chronic ulcers caused by acetic acid, but also for the continued spread of gastric mucosal damage. Several clinical trials have demonstrated the effectiveness of ZAC in the acute and maintenance phase of gastric and duodenal ulcers. Endoscopic observations indicate that ZAC can shorten the inflammatory processes associated with ulcer healing (gastritis and duodenal inflammation). The shortening of this process was not seen in other control treatments (H 2 -receptor blockers), with statistically significant significance. And side effects are small, less than 2%. Given the clinical efficacy and tolerability of ZAC, ZAC is a worthy candidate in the treatment of digestive diseases.