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目的:探讨埃索美拉唑对糜烂性胃溃疡患者血清ERK1/2及EGFR水平的影响及临床疗效。方法:收集我院糜烂性胃溃疡患者106例,随机分为实验组和对照组。对照组予以奥美拉唑治疗,实验组予以埃索美拉唑治疗。检测并比较两组患者治疗前后血清ERK1/2及EGFR水平变化,观察患者溃疡面积、愈合情况以及临床症状的改善情况等。结果:与治疗前比较,治疗后两组患者血清ERK1/2及EGFR水平上升,差异有统计学意义(P<0.05);与对照组比较,实验组治疗后ERK1/2及EGFR水平较高,差异有统计学意义(P<0.05)。与治疗前比较,治疗后两组患者溃疡面积均减小,差异有统计学意义(P<0.05);与对照组比较,实验组治疗后溃疡愈合情况更显著,差异有统计学意义(P<0.05)。与治疗前比较,治疗后两组患者临床症状均获得缓解,差异有统计学意义(P<0.05);与对照组比较,实验组治疗后症状改善更明显,差异有统计学意义(P<0.05)。结论:埃索美拉唑可调节糜烂性胃溃疡患者血清ERK1/2及EGFR水平,改善溃疡情况,缓解临床症状,提高临床疗效,值得临床推广应用。
Objective: To investigate the effect of esomeprazole on serum ERK1 / 2 and EGFR levels in patients with erosive gastric ulcer and its clinical efficacy. Methods: 106 patients with erosive gastric ulcer in our hospital were randomly divided into experimental group and control group. The control group was treated with omeprazole, and the experimental group was treated with esomeprazole. The changes of serum ERK1 / 2 and EGFR levels in both groups before and after treatment were detected and compared. The ulcer area, healing status and the improvement of clinical symptoms were observed. Results: Compared with those before treatment, the levels of ERK1 / 2 and EGFR increased in both groups after treatment (P <0.05). Compared with the control group, the levels of ERK1 / 2 and EGFR in the experimental group were higher, The difference was statistically significant (P <0.05). Compared with those before treatment, ulcer area in both groups decreased after treatment, the difference was statistically significant (P <0.05). Compared with the control group, ulcer healing was more significant in the experimental group after treatment, the difference was statistically significant (P < 0.05). Compared with those before treatment, the clinical symptoms of both groups were relieved after treatment, the difference was statistically significant (P <0.05); Compared with the control group, the symptoms of the experimental group improved more obviously after treatment, the difference was statistically significant (P <0.05 ). Conclusion: Esomeprazole can regulate ERK1 / 2 and EGFR levels in patients with erosive gastric ulcer, improve the ulcer situation, relieve clinical symptoms and improve clinical efficacy, which is worthy of clinical application.