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正常生理条件下,甲状腺受到垂体促甲状腺激素(TSH)的控制。但是,在某些疾病条件下,已发现一些其它的甲状腺刺激物。葡萄胎和绒毛膜上皮癌常伴有甲状腺毒症。推测由滋养叶组织分泌的一种独特的甲状腺刺激物与这些情况下的甲状腺毒症有关。最近,越来越多的证据表明,人绒毛膜促性腺激素(HCG)是滋养叶疾病时刺激甲状腺的诱发因子。作者进行这项研究以期确定HCG是否能结合于人甲状腺膜的TSH受体,以及HCG是
Under normal physiological conditions, the thyroid is controlled by pituitary thyroid-stimulating hormone (TSH). However, some thyroid stimulators have been found under certain disease conditions. Mole and choriocarcinoma are often accompanied by thyrotoxicosis. It is speculated that a unique thyroid stimulus secreted by trophoblast tissues is associated with thyrotoxicosis in these conditions. More recently, there is growing evidence that human chorionic gonadotropin (HCG) is an inducing factor that stimulates the thyroid during trophoblastic disease. The authors conducted this study to determine if HCG binds to the human thyroid membrane TSH receptor, and HCG is