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目的 :观察正脂丸对家兔实验性动脉粥样硬化 (As)形成的影响并探讨其可能的作用机制。方法 :将2 4只新西兰大耳白兔随机分为 4组 ,分别予普通、高脂、含正脂丸 (2 .1g/kg.d)或维生素 E(5 0 m g/kg.d)的高脂饲料 ,于实验前及实验后 4周、8周测定血脂、ox- L DL 和 NO。8周后处死动物 ,测定主动脉粥样硬化指数。结果 :8周后正脂丸组血脂、ox- L DL 显著低于模型组 ,NO高于模型组 ;维生素 E组血脂水平与模型组无显著差异 ,但 ox-L DL 低于模型组 ,NO高于模型组。各组间主动脉粥样硬化指数均有显著差异 ,其中正脂丸组低于维生素 E组。结论 :正脂丸除具有调脂作用外 ,还能抗 L DL 氧化修饰、保护血管内皮功能 ,维生素 E对血脂无明显影响 ,但亦能通过上述途径起到防治 As的作用。
Objective: To observe the effect of Zhengzhi Pills on experimental atherosclerosis (As) in rabbits and to explore its possible mechanism. METHODS: Twenty-four New Zealand white rabbits were randomly divided into four groups and given ordinary, high-fat, orally-fat pills (2.1 g/kg.d) or vitamin E (50 mg/kg.d). In high-fat diets, blood lipids, ox-L DL, and NO were measured before and 4 and 8 weeks after the experiment. Animals were sacrificed after 8 weeks and aortic atherosclerosis index was determined. Results: After 8 weeks, the lipid and ox-L DL levels in the Zhengzhi Pill group were significantly lower than those in the model group, and NO was higher than in the model group. There was no significant difference in serum lipid levels between the vitamin E group and the model group, but the ox-L DL was lower than that in the model group. Model group. Aortic atherosclerosis index was significantly different among the groups, in which the positive fat pill group was lower than the vitamin E group. Conclusion: In addition to lipid-regulating effect, positive-lipid pill can also resist oxidation modification of LDL and protect endothelial function. Vitamin E has no obvious effect on blood lipids, but it can also play a role in prevention and treatment of As through the above-mentioned methods.