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目的:分析慢性乙型肝炎和HBV携带患者的临床资料和肝活检病理结果,为临床诊断HBV携带提供参考。方法:选择慢性乙型肝炎和HBV携带患者,按临床诊断和病理诊断标准分组,比较临床资料和肝活检病理结果。结果:以往临床诊断方法与肝活检病理诊断相比,灵敏度为27.3%,特异度为91.7%,误诊率2.9%,漏诊率72.7%。Kappa=0.147,P=0.024<0.05。结论:以往诊断标准不能全面地代表肝脏炎症、纤维化程度和时期,应用肝活检病理检查,可以更好地弥补以往方法准确性差、灵敏度低的问题。
OBJECTIVE: To analyze the clinical data of patients with chronic hepatitis B and HBV infection and the pathological results of liver biopsy, so as to provide reference for clinical diagnosis of HBV carrier. Methods: Chronic hepatitis B and HBV carriers were selected and grouped according to clinical diagnosis and pathological diagnosis criteria. Clinical data and pathological results of liver biopsy were compared. Results: Compared with the pathological diagnosis of liver biopsy, the past clinical diagnosis method had a sensitivity of 27.3%, a specificity of 91.7%, a misdiagnosis rate of 2.9% and a missed diagnosis rate of 72.7%. Kappa = 0.147, P = 0.024 <0.05. Conclusion: The past diagnostic criteria can not fully represent the degree of liver inflammation, fibrosis and period, the application of liver biopsy pathology, can better make up for the poor accuracy of previous methods, low sensitivity.