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目的：以测血压和脉搏为直接观察指标，测心钠素（ＡＮＰ）为间接观察指标，对比观察两种药物降低插管时的高循环动力的效果。方法：２０例择期肿瘤手术病人，随机分为两组：Ａ组用芬太尼２μｇ／ｋｇ，Ｂ组用乌拉地尔０．５ｍｇ／ｋｇ，于麻醉诱导前５ｍｉｎ应用。分别在术前、用药后５ｍｉｎ，插管后（０ｍｉｎ、５ｍｉｎ、１０ｍｉｎ）测血压、心率并分别抽静脉血测ＡＮＰ。结果：Ａ组用药后ＤＢＰ及ＡＮＰ降低，气管插管后ＡＮＰ恢复，但ＳＢＰ和ＤＢＰ均有升高。Ｂ组用药后ＤＢＰ和ＡＮＰ降低，插管后即刻血压稳定，与Ａ组比较差异有非常显著意义（Ｐ＜０．０１），ＡＮＰ在用药后及插管后即刻有降低，但迅速恢复，心率与术前比较差异有显著性意义。结论：乌拉地尔预防气管插管时心血管反应较小剂量芬太尼有效。
OBJECTIVE: To measure the blood pressure and pulse rate as the direct observation index, to measure the atrial natriuretic factor (ANP) as an indirect observation index, to compare the two drugs to reduce the effect of high circulatory power during intubation. Methods: Twenty patients undergoing elective surgery were randomly divided into two groups: fentanyl 2μg / kg in group A and aliskum 0.5mg / kg in group B, which was applied 5 minutes before induction of anesthesia. Blood pressure and heart rate were measured before operation, 5 min after administration, and ANP was measured after intubation (0min, 5min, 10min). Results: The DBP and ANP in group A were decreased after treatment, ANP recovered after tracheal intubation, but both SBP and DBP increased. DBP and ANP were decreased in group B and blood pressure was stable immediately after intubation. Compared with group A, DBP and ANP had significant difference (P <0.01). ANP decreased immediately after administration and immediately after intubation, but recovered rapidly. Heart rate Compared with the preoperative difference was significant. CONCLUSIONS: Urapidil is effective in preventing cardiovascular responses to smaller doses of fentanyl during endotracheal intubation.