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目的:考察柴菊口服液抗病毒抑菌和抗炎解热作用。方法:采用细胞病变抑制法、琼脂稀释法、小鼠流感病毒感染法来研究柴菊口服液对常见呼吸道病毒和细菌的抑制作用;采用小鼠耳廓肿胀法、小鼠腹腔致炎法和细菌内毒素致家兔发热法研究柴菊口服液的抗炎解热作用。结果:柴菊口服液对流感病毒甲3型(A3)、副流感病毒1型(HVJ)、呼吸道合胞病毒(RSV)、单纯疱疹病毒1和2型(HSV-1,HSV-2)以及所试6种细菌56株菌株均有不同程度的抑制作用,其中对副流感病毒和金葡菌的抑制作用较强。高、中、低剂量(19.2,9.6,4.8 g生药.kg-1)柴菊口服液能不同程度降低流感病毒感染小鼠的肺指数(P<0.01或0.05),增加感染小鼠的体重(P<0.05),减少感染小鼠的死亡率(P<0.05),延长感染小鼠的存活时间(P<0.01或0.05);高中剂量柴菊口服液能显著抑制二甲苯引起的小鼠耳廓炎性肿胀(P<0.05);高、中、低剂量柴菊口服液能够明显降低醋酸引起的小鼠腹腔毛细血管通透性(P<0.01或0.05);高剂量(19.2 g生药.kg-1)柴菊口服液对细菌内毒素引起的家兔体温升高有较好的解热作用(P<0.05)。结论:柴菊口服液具有较明显的抗病毒抑菌和抗炎解热功效。
Objective: To investigate the antibacterial and antipyretic effects of Chaiju oral solution. Methods: The inhibitory effect of Chaiju oral solution on common respiratory viruses and bacteria was studied by cytopathic effect inhibition method, agar dilution method and mouse influenza virus infection method. Mouse auricle swelling method, mouse peritoneal inflammation method and bacteria Anti - inflammatory and antipyretic effects of Chaiju oral solution induced by endotoxin in rabbits. Results: The results showed that Chaiju oral liquid had a positive effect on influenza virus type A (A3), parainfluenza virus type 1 (HVJ), respiratory syncytial virus (RSV), herpes simplex virus 1 and 2 (HSV-1, HSV- The tested six kinds of bacteria 56 strains have different degrees of inhibition, which has a strong inhibitory effect on parainfluenza virus and Staphylococcus aureus. The high, medium and low dose (19.2, 9.6, 4.8 g crude drug kg-1) Chai Ju oral solution can reduce the pulmonary index (P <0.01 or 0.05) of mice infected with influenza virus to different degrees and increase the body weight P <0.05), reduce the mortality of infected mice (P <0.05), prolong the survival time of infected mice (P <0.01 or 0.05); high dose of Chai Ju oral solution can significantly inhibit xylene-induced mouse ear Inflammatory swelling (P <0.05); high, medium and low doses of Chai Ju oral solution can significantly reduce acetic acid-induced mouse peritoneal capillary permeability (P <0.01 or 0.05); high dose (19.2 g crude drug kg- 1) Chaiju oral solution has good antipyretic effect on body temperature caused by bacterial endotoxin in rabbits (P <0.05). Conclusion: Chaiju oral liquid has obvious anti-viral antibacterial and antipyretic effects.