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硫氧还蛋白(Thioredoxin,Trx)/硫氧还蛋白还原酶(Thioredoxin reductase,Trx R)系统在维持生物体的氧化还原平衡中起着重要的作用。Trx R在多种原发性肿瘤部位及患者血清中呈现高表达,与肿瘤的发生、发展进程密切相关。Trx R不仅通过MAPK、NF-κB等信号通路调控肿瘤细胞凋亡,还可以通过影响自噬介导细胞凋亡。此外,免疫细胞的Trx R系统通过调控肿瘤免疫微环境影响肿瘤的生长。因此,靶向Trx R抑制其活性为新型抗肿瘤药物的研究提供了一个新的治疗靶点和策略。本文围绕Trx R系统在肿瘤生物学进程及肿瘤微环境中的研究进展作一综述。
Thioredoxin (Trx) / Thioredoxin reductase (TrxR) system plays an important role in maintaining the redox balance of the organism. Trx R is highly expressed in various primary tumor sites and patient sera, which is closely related to the occurrence and development of tumors. Trx R not only regulates tumor cell apoptosis through MAPK, NF-κB and other signaling pathways, but also mediates apoptosis by affecting autophagy. In addition, the TrxR system of immune cells affects the growth of tumors by modulating the immune immune microenvironment. Therefore, targeting Trx R to inhibit its activity provides a new therapeutic target and strategy for the study of novel anti-tumor drugs. This article reviews the progress of TrxR system in tumor biology process and tumor microenvironment.