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目的:探讨p63蛋白在甲状腺腺瘤、甲状腺乳头状癌、甲状腺滤泡癌、鳞状细胞癌和甲状腺髓样癌中的表达意义,探索这些甲状腺疾病的可能起源,以及这些疾病病因之间有无联系。方法:运用免疫荧光法检测10例甲状腺腺瘤、25例甲状腺乳头状癌、4例甲状腺滤泡状癌、2例髓样癌和2例甲状腺鳞状细胞癌中p63的表达。结果:p63在甲状腺腺瘤、甲状腺乳头状癌、甲状腺滤泡癌、甲状腺鳞状细胞癌和甲状腺髓样癌中均有表达。p63在鳞状细胞癌和髓样癌中表达最高,在甲状腺乳头状癌中其表达与患者年龄、性别、肿块位置、肿块大小和有无转移无明显相关性。结论:①甲状腺组织内存在p63阳性标记的干细胞;②甲状腺乳头状癌、滤泡癌、鳞状细胞癌等可能起源相似。干细胞是多功能细胞,向不同方向分化,形成不同疾病;③p63在甲状腺鳞状细胞癌和髓样癌中表达最高,说明在鳞状细胞癌中残留干细胞较多,与肿瘤的生物学特性一致。
Objective: To investigate the expression of p63 protein in thyroid adenoma, papillary thyroid carcinoma, follicular thyroid carcinoma, squamous cell carcinoma and medullary thyroid carcinoma and to explore the possible origin of these thyroid diseases and the existence of the etiology of these diseases contact. Methods: The expression of p63 in 10 cases of thyroid adenoma, 25 cases of thyroid papillary carcinoma, 4 cases of thyroid follicular carcinoma, 2 cases of medullary carcinoma and 2 cases of thyroid squamous cell carcinoma were detected by immunofluorescence. Results: p63 was expressed in thyroid adenoma, thyroid papillary carcinoma, thyroid follicular carcinoma, thyroid squamous cell carcinoma and medullary thyroid carcinoma. The expression of p63 was the highest in squamous cell carcinoma and medullary carcinoma. There was no significant correlation between the expression of p63 and the age, sex, tumor location, tumor size and metastasis in thyroid papillary carcinoma. Conclusions: ① There are p63-positive stem cells in thyroid tissue; ② Papillary thyroid carcinoma, follicular carcinoma and squamous cell carcinoma may have similar origins. Stem cells are multi-functional cells that differentiate into different directions to form different diseases. (3) The expression of p63 is highest in thyroid squamous cell carcinoma and medullary carcinoma, indicating that more stem cells remain in squamous cell carcinoma and are consistent with the biological characteristics of the tumor.