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骨髓间充质干细胞(bone mesenchymal stemcell,BMSC)是骨髓基质细胞的重要组成部分,由于其不但能与其他细胞一起支持造血干细胞造血,而且还具有较强的增殖功能及多向分化潜能,在一定诱导因素下可定向分化成骨细胞、软骨细胞和脂肪细胞等,近年来已成为生物学和医学的研究热点。本文简要介绍了不同生长因子如血管内皮生长因子、碱性成纤维细胞生长因子、转化生长因子-β等对BMSC增殖、分化的影响。
Bone marrow mesenchymal stem cell (BMSC) is an important part of bone marrow stromal cells. Because it can not only support hematopoietic stem cell hematopoiesis with other cells, but also has strong proliferative function and multi-directional differentiation potential, Inducible factors can be oriented to differentiate into osteoblasts, chondrocytes and adipocytes, in recent years has become a biological and medical research hot spots. This article briefly introduced the effects of different growth factors such as vascular endothelial growth factor, basic fibroblast growth factor and transforming growth factor-β on the proliferation and differentiation of BMSCs.