裸小鼠人癌异种移植及影响移植成功的因素(综述)

• 作 者: 马曾辰 汤钊猷
• 机 构: 上海第一医学院中山医院肝癌研究室,上海第一医学院中山医院肝癌研究室
• 出 处: 国外医学(肿瘤学分册)
• 发表日期: 1982年02期
• 关键词: 裸小鼠 异种移植 无胸腺 实验性治疗 人结肠癌 移植成功率 nude 实验动物 免疫力 免疫功能

一个世纪以来,人们为探索人癌异种移植进行了不懈的努力,但均未获得满意结果。1966年裸小鼠(nude mice)的发现以及证实这种裸小鼠先天性无胸腺,为人癌异种移植提供了较理想的实验动物。1969年Ryg-aard 首先报告人结肠癌在裸小鼠移植成功,此后裸小鼠人癌模型便广泛应用于肿瘤的基础理论及实验性治疗等研究。裸小鼠虽无胸腺,但并非全无免疫力,因此,寻求可靠、稳定的提高移植成功率的方法仍为各国学者所重视。本文综述与此有关的问题。

For more than a century, people have made unremitting efforts to explore human cancer xenotransplantation, but none of them have achieved satisfactory results. The discovery of nude mice in 1966 and the confirmation of congenital absence of thymus in nude mice provided ideal experimental animals for human cancer xenografts. In 1969, Ryg-aard firstly reported that colon cancer was successfully transplanted in nude mice. Since then, the nude mouse model has been widely used in the study of tumor basic theory and experimental treatment. Although nude mice without thymus, but not all immune, therefore, to seek reliable and stable methods to improve the success rate of transplantation remains the focus of scholars in various countries. This article summarizes the issues related to this.