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Virchow首次报告正常眼杯状细胞的密度。Kessing证明杯状细胞在鼻下象限的结膜密度最高,且35岁以后其密度保持稳定。但在各种不同眼病尤其是在干燥性角结膜炎则变化很大。Letup等(1972)指出干燥性角结膜炎的杯状细胞数目增加和粘液过多。Sjogren等(1971)谓干燥性角结膜炎早期杯状细胞数目正常,严重者则数目减少,但在下穹窿部则密度增加。或有人谓其密度取决于病的严重程度。眼瘢痕性类夭疱疮和严重放射性干燥性角结膜炎者杯状细胞密度减少。作者用压印细胞学技术对90例173眼的杯状
Virchow first reported normal goblet cell density. Kessing proved that goblet cells had the highest conjunctival density in the subnasal quadrant and its density remained stable after 35 years of age. However, in a variety of different eye diseases, especially in keratoconjunctivitis sicilian great changes. Letup et al. (1972) noted an increase in the number of goblet cells and hypermucosa in keratoconjunctivitis sicca. Sjogren et al. (1971) said that the number of goblet cells in normal keratoconjunctivitis was normal in the early stage and decreased in severe cases but increased in the inferior fornix. Or someone that its density depends on the severity of the disease. Eye cicatricial type of pemphigus and severe radiation keratoconjunctivitis goblet cells density decreased. The authors used imprint cytology techniques on 90 eyes of 173 cups