乙酰水杨酸钙制备与药动学研究

• 作 者: 邵光汉
• 机 构: 解放军第73医院,
• 出 处: 药学情报通讯
• 发表日期: 1988年02期
• 关键词: 乙酰水杨酸 肠道反应 溶液反应 抗风湿 药动学 毒副作用 作用时间 剂量 血清药物浓度 药对

乙酰水杨酸(AAS)因疗效可靠、作用面宽、毒副作用小等优点而被广泛地应用于临床,但该药对胃粘膜有较强的刺激性,水溶性差(1:300)、小儿分剂量困难等缺点,限制了它的使用范围。我院采用AAS甲醇溶液与乙酸钙水溶液反应制备乙酰水杨酸钙(Calcii Acetylsalicylas,CAS)供临床应用。经3年多实践体会,该药在与AAS相当剂量时,其解热、镇痛、抗风湿等作用都优于后者;具备起效快、作用时间长、胃肠道反应少等特点。

Acetylsalicylic acid (AAS) has been widely used clinically due to its advantages such as reliable curative effect, wide application range and small toxic and side effects. However, the drug has strong irritation to gastric mucosa, poor water solubility (1: 300), pediatric Difficult points and other shortcomings, limiting its scope of use. In our hospital, Calcium Acetylsalicylas (CAS) was prepared by the reaction of AAS methanol solution and calcium acetate solution for clinical application. After more than 3 years of practice experience, the drug at a dose equivalent to AAS, its antipyretic, analgesic, anti-rheumatism and other effects are superior to the latter; with fast onset, long duration of action, less gastrointestinal reactions and so on.