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目的：观察维拉帕米对缺血性急性肾功能衰竭是否具有保护作用。方法：以维拉帕米（１．０ｍｇ／ｋｇ）灌注切除右肾的成年雄性ＳＤ大鼠之左肾，５ｍｉｎ后夹闭左肾动脉４５ｍｉｎ，对照组则灌注生理盐水。再灌注２４ｈ后，观察左肾血流量（ＬＲＢＦ），尿量（ＵＶ），血尿素氮（ＢＵＮ），血肌酐（Ｃｒ），肌酐清除率（ＣＣｒ），左／右肾重量之比（Ｌ／Ｒ，ｋｗ），肾脏组织学评分（ＨＳＫ），尿中Ｎ－乙酰氨基葡萄糖苷酶（ＮＡＧ）和丙氨酸氨基肽酶（ＡＡＰ）活性的变化。结果：与对照组相比，维拉帕米组之ＬＲＢＦ减少较小，ＢＵＮ、Ｃｒ、Ｌ／Ｒ（ｋｗ）、ＨＳＫ较低，ＮＡＧ和ＡＡＰ活性较低，而ＣＣｒ较高。结论：维拉帕米对缺血性急性肾功能衰竭确实具有一定的保护作用。
Objective: To observe whether verapamil has a protective effect on ischemic acute renal failure. Methods: The left kidney of adult male Sprague-Dawley rats with verapamil were perfused with verapamil (1.0 mg / kg) for 45 min. The left renal artery was occluded for 45 min after 5 min. The control group was perfused with saline. After 24 hours of reperfusion, the left renal blood flow (LRBF), urine output (UVB), blood urea nitrogen (BUN), serum creatinine (Cr), creatinine clearance (CCr) R, kw), renal histological score (HSK), urine N-acetylglucosaminidase (NAG) and alanine aminopeptidase (AAP) activity. Results: Compared with the control group, the LRBF decreased slightly in the verapamil group. The BUN, Cr, L / R (kw), HSK were lower, the activities of NAG and AAP were lower, and CCr was higher. Conclusion: Verapamil does have a protective effect on ischemic acute renal failure.