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本文采用具有高度特异性和敏感性的酶联免疾吸附实验（ＥＬＩＳＡ）方法，对２２名高龋者（ＣＡ）及１４外无龋者（ＣＦ）的唾液中抗变链Ｓ．ｍｕｔａｎｓ（Ｃ型）及Ｓ．ｓｏｂｒｉｎｕｓ（ｇ型）全细胞抗原的ＳＩｇＡ抗体进行了测定，结果显示，ＣＦ组特异性抗体水平均明显高于ＣＡ组（Ｐ＜０．０５），而两种变链之间，无论是ＣＡ组或是ＣＦ组ＳＩｇＡ水平均无明显差异（Ｐ＞０．０５）．这表明，成人唾液中自然产生的抗变链ＳＩｇＡ抗体以无龋者明显高于高龋者，提示可能是无龋者唾液中较高水平的抗体抑制了龋病的发生。
In this study, a highly specific and sensitive enzyme-linked immunosorbent assay (ELISA) was used to detect anti-variable strand S in the saliva of 22 patients with high caries (CA) and 14 without caries (CF). mutans (type C) and S. The results showed that the levels of specific antibodies in CF group were significantly higher than those in CA group (P <0.05). However, both of the two variable chains, Or CF group SIgA levels were no significant difference (P> 0.05). This suggests that naturally occurring anti-chain SIgA antibodies in adult saliva were significantly higher in caries-free subjects than in those with high caries, suggesting that caries may be suppressed by higher levels of antibodies in caries-free saliva.