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目的:探讨应用低水平呼吸末正压预防重症中毒借助机械通气所致呼吸机相关性肺炎的作用。方法:将2016年4月-2017年5月期间本院收治的46例重症中毒患者随机分成观察组(23例)与对照组(23例),两组均采取机械通气辅助治疗,在机械通气过程,对照组不用低水平呼吸末正压,观察组加用低水平呼气末正压。观察两组患者呼吸性相关性肺炎发生情况及临床各治疗指标情况。结果:机械通气治疗期间,观察组进出现2例呼吸机相关性肺炎,明显低于对照组7例的发生数,差异有统计学意义(P<0.05);观察组患者在机械通气时间、呼吸性相关性肺炎发生时间、住院时间等指标上明显由于对照组,差异也有统计学意义(P<0.05)。结论:在重症中毒患者使用机械通气治疗期间,使用低水平呼吸末正压能够有效预防呼吸机相关性肺炎发生。
Objective: To explore the role of low level positive end-expiratory pressure in preventing ventilator-associated pneumonia caused by mechanical ventilation with severe poisoning. Methods: Forty-six patients with severe poisoning admitted to our hospital from April 2016 to May 2017 were randomly divided into observation group (23 cases) and control group (23 cases). Both groups received mechanical ventilation, The process, the control group without a low level of positive end-expiratory pressure, the observation group plus a low level of positive end-expiratory pressure. To observe the incidence of respiratory related pneumonia in both groups and clinical treatment of various indicators. Results: During the period of mechanical ventilation, there were 2 cases of ventilator-associated pneumonia in the observation group, which was significantly lower than that in the control group (P <0.05). The observation group had significant differences in mechanical ventilation time, The incidence of sex-related pneumonia, hospital stay and other indicators were significantly different due to the control group, the difference was statistically significant (P <0.05). Conclusions: The use of low levels of positive end-tidal pressure during mechanical ventilation in critically ill patients can effectively prevent the development of ventilator-associated pneumonia.