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目的检测赖氨酸特异性去甲基化酶1(Lysine specific demethylase 1,LSD1)在食管鳞癌以及正常食管组织中的表达,并探讨LSD1与食管鳞癌临床特征、肿瘤增殖及凋亡等的关系。方法免疫组化S-P染色法检测86例食管鳞癌组织及29例正常食管组织中LSD1、增殖相关抗原Ki67的表达情况,TUNEL检测食管鳞癌组织凋亡情况,并分析LSD1表达与患者临床资料、预后以及增殖和凋亡的关系。结果 LSD1在食管鳞癌组织中阳性率(89.5%)明显高于正常组织(51.7%),且与患者淋巴结转移相关(P<0.05),并能明显影响患者的预后(P<0.05),LSD1的表达与肿瘤增殖有关,但与凋亡无关。结论 LSD1在食管鳞癌中高表达且与患者预后相关,可能成为食管鳞癌中值得研究的治疗靶标。
Objective To detect the expression of Lysine specific demethylase 1 (LSD1) in esophageal squamous cell carcinoma and normal esophageal squamous cell carcinoma, and to explore the clinical features of LSD1 and esophageal squamous cell carcinoma, tumor proliferation and apoptosis relationship. Methods Immunohistochemical SP staining was used to detect the expression of LSD1 and Ki67 in 86 esophageal squamous cell carcinomas and 29 normal esophageal tissues. The apoptosis of esophageal squamous cell carcinoma was detected by TUNEL. The expression of LSD1 and clinical data were analyzed. Prognosis and the relationship between proliferation and apoptosis. Results The positive rate of LSD1 in esophageal squamous cell carcinoma (89.5%) was significantly higher than that in normal tissues (51.7%), which was correlated with lymph node metastasis (P <0.05), and significantly affected the prognosis of patients with LSD1 The expression was related to tumor proliferation, but not to apoptosis. Conclusion LSD1 is overexpressed in esophageal squamous cell carcinoma and correlated with the prognosis of patients. It may be a therapeutic target for esophageal squamous cell carcinoma.