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[目的]探讨热休克蛋白60(HSP60)抗体水平与冠心病(CHD)的关系。[方法]采用病例-对照研究方法,选取未治疗过的CHD患者615例为病例组,以同性别、年龄(±1岁)进行1:1匹配,共选取615例无CHD且无重要脏器疾病者为对照组。采用间接酶联免疫吸附法测定血浆HSP60抗体水平,Logistic回归分析HSP60抗体与CHD的关系。[结果]CHD组的HSP60抗体水平明显高于对照组,差异有统计学意义(P=0.000)。在校正了传统的危险因素后,与下四分位数HSP60抗体组相比,上四分位数HSP60抗体组发生CHD的危险度是其2.48(95%CI:1.78~3.46)倍;多支病变的危险度是其3.60(95%CI:1.32~9.83)倍,差异有统计学意义。[结论]HSP60抗体与CHD的发病风险及其严重程度相关,提示HSP60抗体在CHD的发生发展中可能发挥某些作用。
[Objective] To investigate the relationship between antibody level of heat shock protein 60 (HSP60) and coronary heart disease (CHD). [Methods] A case-control study was conducted. 615 untreated patients with CHD were selected as the case group and matched by 1: 1 of the same sex and age (± 1 year). A total of 615 CHD-free and non-vital organs The disease was the control group. Plasma HSP60 antibody levels were measured by indirect enzyme-linked immunosorbent assay (ELISA), and the relationship between HSP60 antibody and CHD was analyzed by Logistic regression. [Results] The level of HSP60 antibody in CHD group was significantly higher than that in control group, the difference was statistically significant (P = 0.000). After adjusting for traditional risk factors, the risk of CHD in the upper tertile HSP60 antibody group was 2.48 (95% CI: 1.78 to 3.46) times greater than in the lower tertile HSP60 antibody group; multiple The risk of disease was 3.60 (95% CI: 1.32-9.83) times, the difference was statistically significant. [Conclusion] HSP60 antibody is associated with the risk and severity of CHD, suggesting that HSP60 antibody may play some roles in the development of CHD.