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[目的 ]探讨米索前列醇终止早孕的最佳剂量和给药途径。 [方法 ]将 310例停经 80天内的早孕要求药物终止妊娠的妇女随机分成两组 :实验组 16 0例 (阴道放置米索前列醇组 ) ,米非司酮2 5mg ,每天 2次 ,连服 3天 ,第 4天晨来院阴道放置米索前列醇 0 .6mg ;对照组 15 0例 (口服米索前列醇组 ) ,米非司酮 2 5mg ,每天 2次 ,首量加倍 ,服完 15 0mg ,第 4天晨来院顿服米索前列醇 0 .6mg。 [结果 ]完全流产率实验组为 94 .38%,高于对照组的 90 %,但无统计学差异 (P >0 .0 5 ) ;胚囊排出时间实验组 3.6 0± 1.81小时 ,慢于对照组的 2 .2 6± 1.5 2小时 ,有显著性差异 (P <0 .0 1) ;流产时平均出血量实验组 16 .6 1± 10 .2 1mL ,明显少于对照组的 2 3.4 2± 12 .5 3mL(P <0 .0 1) ;流产后阴道流血时间实验组平均为 12 .5 6± 5 .82天 ,明显短于对照组的 2 0 .4 5± 11.34天 (P <0 .0 1) ;胃肠道副反应发生率实验组占 6 7.5 %,明显低于对照组的 89.33%(P <0 .0 1)。 [结论 ]阴道放置米索前列醇 0 .6mg继服米非司酮后终止早孕 ,是一种简便、经济、有效和无侵害性的方法 ,阴道出血少、流产后阴道流血持续时间短 ,且胃肠道副反应发生率比口服低 ,米索前列醇阴道给药比口服给药更好 ,该药稳定 ,容易贮存 ,是终止早孕?
[Objective] To investigate the optimal dose and route of administration of misoprostol for early pregnancy termination. [Methods] A total of 310 women with pregnancy discontinuation within 80 days after menopause were randomly divided into two groups: experimental group 160 cases (vaginal misoprostol group) and mifepristone 25mg twice daily 3 days, the first 4 days to the hospital placed misoprostol 0. 6mg; control group of 150 cases (oral misoprostol group), mifepristone 25mg, 2 times a day, the first doubled, served 15 0mg, the first four days of the morning to Dayton hospital misoprostol 0.6mg. [Results] The rate of complete abortion was 94.38% in the experimental group, which was higher than 90% of the control group, but there was no significant difference (P> 0.05). The blastocyst discharge time in the experimental group was 3.6 ± 1.81 hours, The control group had a significant difference (P <0. 01) at 2.26 ± 1.5 2 hours. The average amount of bleeding in the abortion group was 16.61 ± 10.21 mL, which was significantly lower than that of the control group 2 ± 12.53mL (P <0.01). The mean vaginal bleeding time after abortion in experimental group was 12.56 ± 5.82 days, which was significantly shorter than that in control group (P> 0.05) <0.01). The incidence of gastrointestinal side effects in experimental group was 6 7.5%, which was significantly lower than that in control group (89.33%, P 0. 01). [Conclusion] The vaginal placement of misoprostol 0.6mg after mifepristone termination of early pregnancy is a simple, economical, effective and noninvasive method with less vaginal bleeding and short vaginal bleeding after abortion Lower incidence of gastrointestinal side effects than oral administration, misoprostol vaginal administration is better than oral administration, the drug is stable and easy to store, is to terminate early pregnancy?