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天然状态的去氧核糖核酸(DNA)对正常动物并无抗原性。系统性红斑狼疮(SLE)病人有抗DNA的循环抗体以及DNA皮试阳性。一种较罕见的疾病——对DNA自身致敏-也是以DNA皮试阳性为特征,临床表现为反复发作的疼痛性瘀斑而无其他系统性表现,但其病理生理学仍未明。本文报告1例对DNA自身致敏的病人,女性,59岁。1972年因面部、臂部和小腿伴有疼痛性瘀斑4个月而就诊。损害突然自发地出现于手掌、唇、颏、臂部和小腿。初为红色高起之触痛性结节,直径为0.5～2.0cm,数小时后发展为较大的疼痛性瘀斑。损害开始于一个部位,但很快成批地发生于其他部
Natural state of DNA (DNA) is not antigenic in normal animals. Patients with systemic lupus erythematosus (SLE) have anti-DNA circulating antibodies and positive DNA skin tests. A less common disease - sensitized to DNA itself - is also characterized by a DNA dermatitis test that is clinically manifested as recurrent painful ecchymosis with no other systemic manifestations, but its pathophysiology remains unknown. This article reports a case of DNA sensitized patients, female, 59 years old. In 1972 due to the face, arm and leg with painful ecchymosis 4 months and treatment. Damage suddenly and spontaneously appears in the palm, lip, chin, arm and calf. Beginning with the red high-starting painful nodules, the diameter of 0.5 ~ 2.0cm, a few hours later developed into a larger painful ecchymosis. The damage started at one site, but soon took place in batches in other departments