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本文应用免疫细胞化学方法 ,研究正常生育男子、不育男子精液中巨噬细胞水平变化 ,同时 ,分析精液质量参数。结果显示 :不育组精液巨噬细胞显著增高 ;巨噬细胞阳性组与阴性组比较 ,活动率 ,活动力 ,尾部肿胀率均显著降低 ,畸形率明显增高 ;尾部肿胀率 ,畸形率与巨噬细胞含量分别呈负相关和正相关。研究提示 :在男性不育症患者精液中巨噬细胞有较高发生率 ,精液巨噬细胞数量变化可影响精液质量 ,造成男性不育的机理有待进一步研究。
In this paper, immunocytochemistry was used to study the changes of macrophages in normal fertile men and infertile men. Meanwhile, the semen quality parameters were analyzed. The results showed that the sperm macrophages in infertility group were significantly increased. Compared with the negative group, the activity, activity and tails swelling rate were significantly decreased in macrophage positive group and the abnormality rate was significantly increased. The swelling rate, Cell content was negatively correlated and positively correlated. The study suggests that there is a high incidence of macrophages in seminal fluid of male infertility patients, and the quantity of semen macrophages may affect the quality of semen. The mechanism of male infertility remains to be further studied.