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目的 :观察一种新型免疫抑制剂霉酚酸酯 ( MMF )治疗儿童难治性肾病的疗效与不良反应。 方法 :用MMF联合小剂量糖皮质激素治疗 5例儿童难治性肾病 ,其中原发性肾病 3例 ,狼疮性肾炎 ( L N) 2例。 结果 :5例儿童难治性肾病均取得了较好的效果 ,且无明显的毒副反应 ,特别是对 2例环磷酰胺拮抗的狼疮性肾炎不仅临床症状完全消失 ,血沉、免疫球蛋白、循环免疫复合物、血清自身抗体及补体也恢复正常。 结论 :MMF可能是治疗儿童难治性肾病特别是狼疮性肾炎的一种有前途的药物
Objective: To observe the efficacy and side effects of a new immunosuppressive drug, mycophenolate mofetil (MMF), in the treatment of childhood refractory nephropathy. Methods: Five cases of refractory nephropathy were treated with MMF combined with low dose glucocorticoid, including 3 cases of primary nephropathy and 2 cases of lupus nephritis (L N). Results: Five cases of refractory nephropathy in children have achieved good results, and no obvious side effects, especially for 2 cases of cyclophosphamide antagonistic lupus nephritis not only completely disappeared clinical symptoms, erythrocyte sedimentation rate, immunoglobulin, Circulating immune complexes, serum autoantibodies and complement also returned to normal. CONCLUSIONS: MMF may be a promising drug for the treatment of refractory kidney disease in children, especially lupus nephritis