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采用高效液相色谱法测定大鼠静脉注射芍药苷和灌胃给予白芍煎剂后血浆中芍药苷浓度,静脉注射后的数据经3P87处理,灌胃后的数据以非隔室模型处理.结果表明大鼠静脉注射芍药苷(15mg/kg)后,血药浓度时间曲线符合二室模型,药动学参数为T1/2α=26min,T1/2β=274min.大鼠灌胃白芍煎剂(相当于芍药苷850mg/kg)后,生物利用度为F=312%,Tmax=102min,Cmax=993mg/L.大鼠灌胃白芍煎剂后芍药苷的绝对生物利用度仅为3%,提示芍药苷有可能发生了生物转化.
The plasma concentration of paeoniflorin was determined by intravenous injection of Paeoniflorin and intragastric administration of Paeoniflorin in rats by high performance liquid chromatography. The data after intravenous injection were treated with 3P87 and the data after intragastric administration were treated with a non-compartmental model. The results showed that the time course of plasma concentration of peonifloride (15mg/kg) in rats accorded with the two-compartment model. The pharmacokinetic parameters were T1/2α=26min and T1/2β=274min. Equivalent to 850 mg/kg of paeoniflorin, the bioavailability was F=312%, Tmax=102 min, and Cmax=993 mg/L. The absolute bioavailability of paeoniflorin after intragastric decoction in rats was only 3%. It suggests that there may be biotransformation of paeoniflorin.