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目的:探究脊柱侧弯矫形术术后患者使用氟比洛芬酯注射液镇痛效果的影响因素,为制定术后镇痛方案提供参考.方法:选取2016年6 ～ 12月于南京市鼓楼医院脊柱外科行择期脊柱后路植骨融合内固定术的患者185例,患者均在术后使用氟比洛芬酯注射液镇痛.收集患者性别和年龄分布、脊柱侧弯类型、ASA分级、术中出血量、麻醉方式、术中镇痛用药方案等信息,术后6,24,48,72 h对患者的疼痛情况进行评估,并进行疼痛单因素及多因素Lo-gistic回归分析.结果:除了术后24h与术后48 h之间的NRS评分差异无统计学意义(P＞0.05)外,其他各个时间点间NRS评分的差异均有统计学意义(P＜0.01).多因素Logistic回归分析结果显示,麻醉方式(OR =2.403)、术中出血量(OR=1.001)、术后是否使用患者自控镇痛泵(PCA)(OR =0.219)、心率(OR=0.976)是术后24h疼痛的影响因素(P ＜0.05).而脊柱侧弯类型(OR =0.432)、术前血红蛋白(Hb)含量(OR =0.964)、术后是否使用PCA(OR=0.275)是术后48 h疼痛的影响因素(P＜0.05).结论:医务人员可根据疼痛的影响因素预测术后使用氟比洛芬酯注射液镇痛效果,制定合理的镇痛方案,减少过度镇痛和镇痛不足的发生.","Objective:To explore influence factors of postoperative analgesia by flurbiprofen axetil injection after scoliosis surgery,providing reference for postoperative analgesia program.Methods:Selected 185 patients who treated by flurbiprofen axetil injection after spinal surgery of posterior spinal bone graft and inteal fixation in Nanjing Drum Tower Hospital from June to December in 2016.Gender and age distribution of patients,scoliosis type,ASA class,intraoperative bleeding,anesthesia method,analgesia program of intraoperative were collected.The patients' pain of postoperative 6h,24h,48h,72h was assessed,influence factors of postoperative analgesia by flurbiprofen axetil injection after scoliosis surgery were analyzed by logistic regression.Results:There was no significant difference in NRS scores between postoperative 24h and postoperative 48h (P ＞ 0.05).The differences of NRS scores between the other time points was statistically significant (P ＜ 0.01).Multivariate logistic regression analysis showed that the anesthesia method (OR =2.403),intraoperative blood loss (OR =1.001),use of patient controlled analgesic (PCA) pump after surgery (OR =0.219),heart rate (OR =0.976) were the pain factors of the postoperative 24h (P ＜ 0.05).The forms of scoliosis (OR =0.432),preoperative Hb levels (OR =0.964),use of PCA after surgery (OR =0.275) were the pain factors postoperative 48h (P ＜ 0.05).Conclusion:Medical staff can predict postoperative analgesia by flurbiprofen axetil injection after scoliosis surgery according to pain influence factors,make reasonable analgesia plan,reduce the occurrence of excessive analgesia and inadequate analgesia.