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慢性丙型肝炎病人β干扰素治疗期间出现血清转氨酶升高的原因尚不清楚。本文报道该药所致血清ALT显著升高病人肝组织学检查结果,并探讨这种血清ALT升高的意义。 方法:慢性肝炎的诊断根据肝穿刺活检病理结果。所有病人HBsAg阴性,抗HCV和HCV-RNA阳性,并排除妊娠、肝硬化、自身免疫性疾病或其他严重疾患。治疗采用注射人β干扰素6MU/d,分1/12h和1/24h两组,共6-8周。每周测血清ALT2次,若ALT升高超过治疗前3倍,则再次肝穿刺活检。慢性肝炎的组织学分级分期按Desmet等的标准。
The cause of elevated serum aminotransferases during the treatment of interferon-beta in patients with chronic hepatitis C remains unclear. This article reports the serum ALT caused by the drug significantly increased in patients with liver histology results, and explore the significance of elevated serum ALT. Methods: The diagnosis of chronic hepatitis was based on liver biopsy findings. All patients were negative for HBsAg, were positive for anti-HCV and HCV-RNA, and excluded pregnancy, cirrhosis, autoimmune diseases or other serious illnesses. Treatment with injection of human interferon beta 6MU / d, 1 / 12h and 1 / 24h two groups, a total of 6-8 weeks. Serum ALT2 times a week, if ALT increased more than 3 times before treatment, then again liver biopsy. Histopathological grading of chronic hepatitis according to Desmet and other standards.