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目的 :检测MEBO对家兔内毒素血症血液粘度和TNF -α的影响。方法 :利用LBY -N6型血液粘度计测定在 1 1 5s-1和 1 0s-1切变率下的血液粘度。采用ELISA双抗体夹心法检测TNF -α水平。结果 :试验组注射内毒素前后血液粘度相比P >0 0 5。对照组注射内毒素前后血液粘度相比P <0 0 1。内毒素血症TNF -α水平试验组与对照组相比P <0 0 5。结论 :MEBO可改善内毒素血症血液粘度 ,可降低内毒素血症TNF -α水平。
Objective: To investigate the effect of MEBO on blood viscosity and TNF-α in rabbits with endotoxemia. Methods: Blood viscosity was measured at 1 15s-1 and 1 0s-1 shear rates using a LBY-N6 blood viscometer. ELISA double antibody sandwich method to detect TNF-α levels. Results: The blood viscosity of the experimental group before and after injection of endotoxin compared with P 0 05. The blood viscosity of the control group before and after injection of endotoxin was P <0.01. Endotoxemia TNF-α levels in the experimental group compared with the control group P <0 05. Conclusion: MEBO can improve the blood viscosity of endotoxemia and decrease the level of TNF-α in endotoxemia.