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本文报告9例糖尿病尸检,男8例,女1例。做PAM、PAS、PAP染色(查IgG、IgA、IgM),2例冰冻切片做直接IF法与PAP法对比。观察到微血管病累及各脏器细动脉、毛细血管、细静脉,甚至眼睑、口唇、膀胱、颌下腺和主动脉自养血管。三种Ig普遍沉积于毛细血管壁上。各内分泌腺(如胸腺,垂体,肾上腺,甲状腺,胰岛等处)病变亦甚明显,有待今后进一步研究。作者并发现自身免疫病患者的皮肤、骨骼肌的微血管改变经常与肾脏、心肌内微血管改变同步,建议开展皮肤及骨骼肌活检以了解本病内脏血管情况,供临床治疗参考。
This article reports 9 cases of diabetic autopsy, 8 males and 1 female. Do PAM, PAS, PAP staining (check IgG, IgA, IgM), 2 cases of frozen sections do direct IF method and PAP method comparison. Microvascular disease was observed involving the arteries, capillaries, veins, and even the eyelids, lips, bladder, submandibular glands and aortic autotrophic vessels of various organs. Three kinds of Ig are commonly deposited on the capillary wall. The endocrine glands (such as the thymus, pituitary, adrenal, thyroid, islet, etc.) lesions are also very obvious, pending further study. The authors also found that patients with autoimmune diseases of the skin, skeletal muscle microvascular changes are often synchronized with the kidneys, myocardial microvascular changes, it is recommended to carry out skin and skeletal muscle biopsy to understand the situation of visceral blood vessels for clinical treatment reference.