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目的探讨儿童IgA肾病的临床与病理特点及相互关系。方法对我院2002年3月至2009年7月经肾穿刺活检确诊为IgA肾病的47例患儿的临床表现、肾组织光镜、免疫组化及相关实验室检查进行回顾性分析。结果IgA肾病患儿平均发病年龄(10.0±2.4)岁,男∶女比例为1.94∶1。47例患儿中,临床表现为孤立性血尿型5例(10.64%),孤立性蛋白尿型2例(4.26%),血尿蛋白尿型20例(42.55%),肾病综合征型7例(14.89%),肾炎型13例(27.66%)。病理改变以Ⅲ级为主,免疫球蛋白沉积以复合型为主。结论儿童IgA肾病以学龄期儿童多见,男性明显多于女性。临床表现多样,且临床与病理有一定的关系。病理分级较重及免疫沉积为复合型者,应早期诊断、早期治疗。
Objective To investigate the clinical and pathological features and their relationship of childhood IgA nephropathy. Methods A retrospective analysis was performed on 47 cases of IgA nephropathy diagnosed by renal biopsy in our hospital from March 2002 to July 2009 with light microscope, immunohistochemistry and related laboratory tests. Results The average age at onset of IgA nephropathy was (10.0 ± 2.4) years old. The male / female ratio was 1.94: 1.47. The clinical manifestations were isolated hematuria (5 cases, 10.64%), solitary proteinuria (4.26%), 20 cases of urine proteinuria (42.55%), 7 cases of nephrotic syndrome (14.89%) and 13 cases of nephritis (27.66%). The main pathological changes to grade Ⅲ, immunoglobulin deposition to compound based. Conclusion Children with IgA nephropathy are more common in school-age children, with significantly more males than females. Various clinical manifestations, and clinical and pathological have a certain relationship. Severe pathological grading and immune deposition complex type, should be early diagnosis and early treatment.