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脊髓灰质炎病毒有3个血清型,近年来我国流行的毒株以Ⅰ型为主,在病人中已经全程基础免疫者的所占比例有增高趋势,1989年为9.2%,1990年为12.4%,1991年(1～9月)达20.4%,流行中过去很少见到的四肢麻痹病例不但可以见到,而且个别暴发流行区占全部病例的3～5%,为了解毒株有无差异,我们用 WHO 提供的用于区别野毒株和疫苗株的6株抗Ⅰ型脊灰病毒的单克隆抗体进行微量中和试验检查;方法和判断标本按 WHO 实验手册的规定进行,结果如下:
Poliovirus has three serotypes in recent years, the strains of the epidemic in our country mainly in type I, the proportion of patients who have been the basis of the total immunization has an increasing trend in 1989 was 9.2% in 1990 was 12.4% , 1991 (January to September) reached 20.4%. In the epidemic, rare cases of limb paralysis were not only seen, but individual outbreaks accounted for 3 to 5% of all cases. To find out whether the strains were different, We use the WHO provided for the six strains of wild-type and vaccine strains of monoclonal antibodies against type I poliovirus neutralization test for micro-neutralization; test methods and judgments according to the provisions of the WHO experimental manual, the results are as follows: