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β_2微球蛋白(β_2m)是一种低分子蛋白质,1968年在尿中发现,其后在淋巴细胞和其他有核细胞细胞膜上发现,在血浆中以游离的单体存在。β_2m的功能不清楚,但它同免疫遗传系统密切联系,是构成组织相容性抗原复合物的组成成分。血清β_2m浓度和肾脏功能密切相关,肾脏是它的主要清除器官。β_2m增高见于病毒感染(包括人类免疫缺陷病毒)、恶性淋巴组织增生病和各种自身免疫病。突眼性甲状腺肿和桥本氏病均属自身免疫疾病,由淋巴细胞的活性增加所致。本文作者测定了通过保守治疗或手术摘除的桥本氏病患者血清中β_2m浓度,并与单纯性甲状腺肿次全切除后所引起的甲状腺功能低下的病人及健康对照者作了比较。该项研究中98位病人和30位健康人均无肾脏疾病(血肌肝在正常范围),也无恶性肿瘤迹象。病人被分为三组,A组中包括22例桥本
β_2 microglobulin (β_2m) is a low-molecular-weight protein found in the urine in 1968 and later found on the membranes of lymphocytes and other nucleated cells, as free monomers in the plasma. The function of β_2m is unclear, but it is closely linked to the immune system and is a component of the histocompatibility antigen complex. Serum β_2m concentration and renal function are closely related to the kidney is its main organ of removal. β_2m increased seen in viral infections (including human immunodeficiency virus), malignant lymphoproliferative disease and a variety of autoimmune diseases. Outpatient goiter and Hashimoto’s disease are autoimmune diseases caused by increased lymphocyte activity. The authors determined the concentration of β_2m in the serum of patients with Hashimoto’s disease who had undergone conservative or surgical excision and compared them to those with hypothyroidism and subgroups of healthy controls following subtotal removal of simple goiter. In this study, 98 patients and 30 healthy people had no kidney disease (blood liver in the normal range) and no signs of malignancy. The patients were divided into three groups, including 22 Hashimoto in group A.