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目的:探讨孕中、晚期胎儿纤维蛋白(fFN)、人绒毛膜促性腺激素(hCG)及孕妇宫颈长度在早产预测中的价值。方法:抽取2012年5月~2013年12月绵阳市妇幼保健院接收的160例先兆早产孕妇,取宫颈阴道分泌物经ELISA法检测fFN、hCG水平,采用阴道B超对宫颈长度进行测量,对比单独检测指标与三项联合检测指标的早产预测结局。结果:fFN检测阳性孕妇早产率为84.2%,hCG检测阳性孕妇早产率为71.7%,宫颈长度<25 mm孕妇早产率为83.3%,宫颈长度≥25 mm孕妇早产率为12.5%,fFN与hCG阳性检测联合宫颈长度预测孕妇早产率为97.2%,联合检测的平均敏感度、平均特异度、阳性率、阴性率依次为98.6%、60.4%、95.9%、99.7%。结论:孕中、晚期fFN、hCG联合孕妇宫颈长度检测在早产预测中价值显著,临床应用价值较高。
Objective: To investigate the value of fetal fibrin (fFN), human chorionic gonadotropin (hCG) and cervical length in pregnant women in the prediction of preterm labor. Methods: From May 2012 to December 2013, Mianyang MCH received 160 pregnant women with threatened preterm labor. Cervical vaginal secretions were collected to detect the levels of fFN and hCG by ELISA. The cervical length was measured by vaginal ultrasonography. Prevalence of preterm birth with single test and three combined tests. Results: The preterm birth rate was 84.2% in fFN positive pregnant women, 71.7% in hCG positive pregnant women, 83.3% in pregnant women with cervical length less than 25 mm, and 12.5% in pregnant women with cervical length ≥ 25 mm. The positive rates of fFN and hCG The preterm birth rate of pregnant women predicted by combined cervical length was 97.2%. The average sensitivity, average specificity, positive rate and negative rate of combined detection were 98.6%, 60.4%, 95.9% and 99.7%, respectively. Conclusion: The detection of cervical length by fFN and hCG combined with pregnant women in the second and third trimester is of great value in the prediction of preterm labor and has high clinical value.