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目的:了解妊娠期间红细胞各项参数、锌原卟啉、血清铁在不同孕期的变化规律,为孕期贫血的诊断提供依据。方法:采用全血细胞分析仪、国产ZPP-3800型血液锌原卟啉测定仪、全自动生化分析仪测定孕妇红细胞各参数、锌原卟啉及血清铁水平。结果:随孕周的增加,红细胞、血红蛋白、红细胞比积、平均红细胞体积、平均红细胞血红蛋白含量下降(P<0.01),红细胞分布宽度、锌原卟啉增高(P<0.01)。平均红细胞体积、平均红细胞血红蛋白含量以产后组为最低(P<0.01),红细胞分布宽度以产后组为最大(P<0.05)。孕晚期血清铁明显低于孕早期和孕中期(P<0.01)。结论:孕晚期血清铁下降明显,红细胞有向小细胞低色素发展的趋势,因此,在怀孕的中、晚期,应及时补充铁剂,防止缺铁性贫血的发生。
Objective: To understand the various parameters of erythrocyte during pregnancy, zinc protoporphyrin, serum iron in different pregnancy patterns, provide the basis for the diagnosis of anemia during pregnancy. Methods: The whole blood cell analyzer, domestic ZPP-3800 blood zinc protoporphyrin analyzer and the automatic biochemical analyzer were used to determine the parameters of red blood cells, zinc protoporphyrin and serum iron in pregnant women. Results: With the increase of gestational age, the contents of erythrocyte, hemoglobin, hematocrit, mean erythrocyte volume and mean erythrocyte hemoglobin decreased (P <0.01), the distribution width of erythrocytes and zinc protoporphyrin increased (P <0.01). The average volume of erythrocytes, the average hemoglobin content in the postpartum group was the lowest (P <0.01), and the distribution width of the erythrocytes was the largest in the postpartum group (P <0.05). Serum iron in third trimester was significantly lower than that in early pregnancy and second trimester (P <0.01). Conclusion: Serum iron decreased significantly in the second trimester, and erythrocytes tended to develop the development of small cell hypochromia. Therefore, in the middle and late stages of pregnancy, the iron should be supplemented in time to prevent the occurrence of iron deficiency anemia.